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Vitamin B12

Methylcobalamin

Nutrient Form:
Vitamin
Found In:
Beef Liver, Shellfish & Fish
Bioavailability:
Methylcobalamin is the natural form of vitamin B12 that is found in foods. It has been shown in studies to have comparable absorption rates as synthetic forms of vitamin B12, but yields greater retention in the body over longer periods of time.

Description

Vitamin B12 is a key component in producing methyl groups in your body responsible for synthesizing certain neurotransmitters and hormones involved in mood and cognitive function. It has been found in depleted amounts after long-term antidepressant use, so we included it to replenish it back to normal levels.
Balances Biochemistry
Vitamin B12 is a key component in producing methyl groups responsible for synthesizing certain neurotransmitters and hormones involved in mood, memory, and focus. This balances the body’s natural neurological functions to help with healthy, sustainable neurotransmitter production.
Replenishes Key Nutrients
Vitamin B12 has been found to be depleted among people taking certain antidepressants. We've included it in our Restore formula to ensure that your body maintains healthy nutritional levels.

Ingredients Backed By Science

We review extensive clinical research, so you can feel confident about what you’re putting into your body. We’ve included a few key studies below, so you can evaluate the clinical results too.

Australian National University

Oral Folic Acid and Vitamin B12 Supplementation to Prevent Cognitive Decline in Community-Dwelling Older Adults with Depressive Symptoms

Supplementing with Vitamin B12 and Folic Acid in long-term settings saw improvement in cognitive function, including the reduction in psychological stress.
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Australian National University

Oral Folic Acid and Vitamin B12 Supplementation to Prevent Cognitive Decline in Community-Dwelling Older Adults with Depressive Symptoms

Vitamin B12 and Folic Acid in long-term settings saw improvement in cognitive function, including the reduction in psychological stress.
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Ordu University

The Relationship of Severity of Depression with Homocysteine, Folate, Vitamin B12, and Vitamin D Levels in Children and Adolescents

Results found that supplementing Vitamin D deficiencies can help mitigate side effects related to mood and irritability.
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California Institute of Behavioral Neurosciences & Psychology

Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depression

Review of 30+ clinical studies that found individuals with depression symptoms were consistently depleted in Vitamin B12 levels.
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Kuopio University Hospital

High Vitamin B12 Level and Good Treatment Outcome May be Associated in Major Depressive Disorder

Results showed that Folate supplementation improved overall mood levels in individuals.
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Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University

Status of Vitamins B12 and B6 but Not of Folate, Homocysteine, and the Methylenetetrahydrofolate Reductase C677T Polymorphism are Associated with Impaired Cognition and Depression in Adults

Found a deficiency in B-Vitamins can adversely impact mental health and that supplementing with key B-Vitamins can improve mood and cognition in individuals.
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Rush University Medical Center

Longitudinal Association of Vitamin B6, Folate, and Vitamin B12 with Depressive Symptoms Among Older Adults Over Time

Found a deficiency in B-Vitamins can adversely impact mental health and that supplementing with key B-Vitamins can improve mood and cognition in individuals.
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MRC Neuropsychiatric Research Laboratory

Treatment of Depression: Time to Consider Folic Acid and Vitamin B12

Found a correlation between B-Vitamin deficiencies with mood and cognition, as well as decreasing levels of certain molecules that have been linked to mood disorders.
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Tabriz University of Medical Sciences

Nutritional Status in Patients with Major Depressive Disorders

Results indicate that supplementing with Folate and Vitamin B12 can help address key nutritional factors contributing to mood and cognitive disorders.
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Ulster University; St James's Hospital, Dublin; Trinity College Dublin; Causeway Hospital; Altnagelvin Hospital; St James's Hospital

B-Vitamins in Relation to Depression in Older Adults Over 60 Years of Age

Found a deficiency in B-Vitamins can adversely impact mental health and that supplementing with key B-Vitamins can improve mood and cognition in individuals.
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